August 20, 2022 5 min read

THE DIFFERENCE BETWEEN FULL-SPECTRUM CBD AND EPIDIOLEX

Epidiolex contains cannabidiol (CBD), a compound derived from marijuana (also called marijuana). Epidiolex is the first FDA-approved cannabis-based medication. It was a prohibited substance until it was cleared for use in 2018. However, Epidiolex will no longer be a controlled substance as of April 2020.

 Full-spectrum CBD is a compound derived from the cannabis plant that contains all of the extracts naturally found in the plant, including trace quantities of THC, the psychoactive element responsible for the marijuana "high." It has recently gained popularity to ease a range of health conditions—including pain, anxiety, inflammation, and epilepsy—but additional research is needed to support all of the advantages fully. Discussed below is a summary of how Epidiolex differs from Full-spectrum CBD.

What Is Epidiolex

 According to Lattanzi et al. (2021), Epidiolex is a prescription medication used to treat seizures in kids aged 1 year and older with Lennox-Gastaut syndrome, Dravet syndrome, or tuberous sclerosis complex. Epidiolex is not known to be safe or effective in children under one year. One may be wondering whether it will have the same effect as cannabis on a child's body. Cannabis comprises two compounds: tetrahydrocannabinol (THC) and cannabidiol (CBD). These chemicals have a variety of physiological effects. THC can give you a "high" or euphoric feeling. However, CBD does not provide this effect.

Epidiolex For Ailments

Epidiolex is the first FDA-approved cannabidiol-based medication (CBD). Numerous investigations are being conducted to determine other applications for CBD in medical therapy. Several of these potential applications are discussed below.

Pain Reliever

Epidiolex is not FDA-approved for the treatment of pain. CBD has been found in animal studies to help alleviate pain. However, according to Wallace et al. (2020), fewer trials have been conducted to determine the safety and efficacy of CBD for the treatment of pain in humans. For additional information, see the section below under "Epidiolex for pain treatment."

Anxiety

Epidiolex is not FDA-approved for the treatment of anxiety. Moltke& Hindocha (2021) showed that CBD might help alleviate anxiety by reducing anxious feelings during stressful periods.

Epidiolex Dosage

 According to Ben-Zeev (2020), the Epidiolex dosage prescribed by a doctor will be determined by several factors. These include the following:

  • Child's weight
  • The underlying condition/
  • The severity of the child's seizures
  • The child's liver function
  • other medications the child’s taking

The following information outlines commonly used or suggested dosages. Take care, however, to adhere to the dosage prescribed by the physician. Your doctor will determine the appropriate dosage for you or your child.

Limitations of Epidiolex

 Sekar& Pack (2019) reported that the side effects of Epidiolex can range from minor to severe. Some of the most prevalent side effects of Epidiolex are listed here. This isn't a complete list of possible side effects. To learn more about Epidiolex's possible side effects and how to deal with a bothersome side effect, speak with your doctor or pharmacist. The Food and Drug Administration (FDA) monitors adverse reactions to products it approves. Among the more common Epidiolex side effects include the following:

  • Exhaustion
  • Drowsiness, a sense of weakness malaise
  • Appetite loss
  • Diarrhea rash on the skin insomnia
  • Bacterial infections

What is Full-spectrum CBD?

Full-spectrum CBD is derived from hemp and contains a variety of additional cannabinoids and CBD. This comprises terpenes, important vitamins, proteins, fatty acids, trace levels of THC, and other naturally occurring components found in hemp. Full-spectrum CBD oil is occasionally referred to as "whole-plant" oil since it contains all of the beneficial components of the hemp plant. According to some CBD enthusiasts, full-spectrum CBD products are more efficient than other types since they contain all of the components found in the cannabis plant and up to 0.3 percent THC. This combination results in an "entourage effect," which means that the components of full-spectrum CBD may operate better together than a single cannabinoid does alone.

What Can Full Spectrum CBD Oil Be Used For

 Abernethy (2019) noted that The United States Food and Drug Administration (FDA) had approved only one cannabis-derived pharmaceutical, Epidiolex, a prescription treatment intended to treat particularly severe forms of epilepsy. Maayah et al. (2020) noted that full-spectrum CBD might have the following benefits: joint discomfort, Pain and Inflammation, Soreness and muscle recovery, and Depression and anxiety. Additionally, users consume CBD for various reasons, and the benefits experienced vary according to the mode of consumption and several other circumstances. In essence, customers consume full spectrum CBD for the same reasons they consume any other CBD product. Whatever reason you sought treatment from CBD, full-spectrum CBD will likely be more helpful than broad-spectrum CBD or CBD isolate. That is because broad-spectrum CBD extracts the entirety of the plant's goodness—the benefits extend far beyond the CBD itself.

What Is In Full Spectrum CBD 

The cannabis plant contains over 100 cannabinoids. CBD, or cannabidiol, is a representative of this class of chemicals. THC, CBC, CBG, and CBN are also common cannabinoids. THC (Tetrahydrocannabinol) is the active ingredient in marijuana. It is psychoactive, the cannabinoid responsible for marijuana's eponymous "high." According to Swift et al. (2013), the following phytocannabinoids have the following effects: CBG (Cannabigerol) also possesses anti-inflammatory, antifungal, and tumor-fighting effects. It is undergoing clinical trials to determine whether it benefits cancer, glaucoma, inflammation, and even skin problems. CBN (Cannabinol) is best known for having the most sedative effect of all cannabinoids.

Additionally, CBN is anticonvulsant and anti-inflammatory. Full-spectrum CBD oil combines the benefits of all of these chemicals (and more) to provide customers with enhanced outcomes. Apart from cannabinoids, full-spectrum CBD contains important vitamins, lipids, and proteins.

Conclusion

How CBD works depends on your preferences and openness to try new things. Before deciding which one is best, there are many preparations. Make sure there are a few different options available in case of need. Only CBD is found in Epidiolex. It is safe for usage by adults and children over the age of one year because it does not contain THC.

References

Abernethy, A. (2019). Hemp Production & 2018 Farm Bill. US Food and Drug Administration.

Ben-Zeev, B. (2020). Medical cannabis for intractable epilepsy in childhood: A review. Rambam Maimonides medical journal11(1).

Lattanzi, S., Trinka, E., Striano, P., Rocchi, C., Salvemini, S., Silvestrini, M., & Brigo, F. (2021). Highly Purified Cannabidiol for Epilepsy Treatment: A Systematic Review of Epileptic Conditions Beyond Dravet Syndrome and Lennox–Gastaut Syndrome. CNS drugs35(3), 265-281.

Maayah, Z. H., Takahara, S., Ferdaoussi, M., & Dyck, J. R. (2020). The molecular mechanisms that underpin the biological benefits of full-spectrum cannabis extract in the treatment of neuropathic pain and inflammation. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease1866(7), 165771.

 

Moltke, J., & Hindocha, C. (2021). Reasons for cannabidiol use: a cross-sectional study of CBD users, focusing on self-perceived stress, anxiety, and sleep problems. Journal of cannabis research3(1), 1-12.

Sekar, K., & Pack, A. (2019). Epidiolex as adjunct therapy for treatment of refractory epilepsy: a comprehensive review with a focus on adverse effects. F1000Research8.

Wallace, J. E., Kogan, L. R., Carr, E. C., & Hellyer, P. W. (2020). Motivations and expectations for using cannabis products to treat pain in humans and dogs: a mixed methods study. Journal of cannabis research2(1), 1-12.

Swift, W., Wong, A., Li, K. M., Arnold, J. C., & McGregor, I. S. (2013). Analysis of cannabis seizures in NSW, Australia: cannabis potency and cannabinoid profile. PloS one8(7), e70052.