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  • November 07, 2023 2 min read


    Lion's Mane mushroom (Hericium erinaceus) has garnered attention for its potential health benefits, particularly in the realm of cognitive health. However, like any dietary supplement or natural remedy, it may come with potential side effects. In this article, we will explore the common side effects associated with Lion's Mane, drawing insights from UK government agencies, the National Health Service (NHS), and academic works from renowned UK universities and medical experts.

    Introduction to Lion's Mane

    Before diving into its potential side effects, it's important to understand Lion's Mane. This unique mushroom, known for its cascading, icicle-like appearance, contains bioactive compounds like hericenones and beta-glucans, which have generated interest for their potential health benefits.

    The Cognitive Benefits of Lion's Mane

    Enhanced Cognitive Function

    Lion's Mane is primarily associated with cognitive health. Users have reported improved memory, focus, and mental clarity when taking Lion's Mane supplements. These cognitive enhancements are often attributed to the mushroom's potential to promote the release of nerve growth factor (NGF), a protein that supports nerve cell growth and maintenance.

    Nerve Health Support

    Lion's Mane has been studied for its potential to support nerve health and regeneration, offering potential relief for those with nerve-related conditions and discomfort.

    Common Side Effects

    Gastrointestinal Upset

    Some users have reported gastrointestinal side effects when taking Lion's Mane, such as stomach discomfort, diarrhea, or bloating. These effects may be more common when taking high doses.

    Allergic Reactions

    While rare, allergic reactions to Lion's Mane have been reported. Symptoms can range from skin rashes to more severe reactions, such as difficulty breathing or anaphylaxis. Individuals with known mushroom allergies should exercise caution.

    Sleep Disruptions

    While some users report improved sleep quality, others may experience sleep disruptions when taking Lion's Mane. This can include difficulties falling asleep or having vivid dreams.


    In some cases, Lion's Mane may lead to overstimulation, resulting in symptoms such as restlessness, increased heart rate, or jitteriness. These effects are more likely to occur with high doses.

    Individual Variability

    It is crucial to recognize that individual responses to Lion's Mane can vary. Factors such as dosage, overall health, and underlying medical conditions can influence the likelihood and severity of side effects. As with any supplement, it is advisable to start with a low dose and gradually increase as needed while monitoring for adverse reactions.

    Medical Guidance

    If you are considering Lion's Mane and have concerns about potential side effects, it is advisable to consult with a healthcare provider. They can provide personalized guidance, assess your health status, and help determine the appropriateness of Lion's Mane for your specific needs.


    Lion's Mane is primarily recognized for its cognitive and nerve health benefits. While it is generally considered safe, it may lead to side effects in some individuals. Understanding the potential side effects and consulting with a healthcare provider can help individuals make informed decisions about its use. The insights in this article are drawn from UK government agencies, the NHS, and academic works from renowned UK universities and medical experts, providing a comprehensive understanding of the common side effects of Lion's Mane.